![]() In 1949 Dubnoff found that choline could only act as a donor under aerobic conditions, when it was oxidized to betaine. Of these only betaine and dimethylthetin served as methyl donors. A series of deuterium-labeled methylated compounds were synthesized by du Vigneaud's group, including arsenocholine, trimethylamine, dimethylglycine, and dimethylthetin. The mechanism of transmethylation was then examined. In Foundations of Modern Biochemistry, 1995 Mechanism of Transmethylation It has been suggested that glycine and betaine may act indirectly on glycine metabolism and glycine-mediated neuronal inhibition, enhance GABA activity, or may have a nonspecific effect on biological membranes. Two attempts to withdraw the DMG caused dramatic increases in seizure frequency. ![]() Within 1 week of starting DMG, seizure frequency dropped to three per week. Despite treatment with phenobarbital and carbamazepine, the patient had an average of 16 to 18 generalized seizures each week. ![]() ![]() 105,106 Roach and Carlin 108 reported a striking decrease in seizure frequency in a patient with long-standing mental retardation when 90 mg of DMG was administered twice daily. 103-107ĭMG has also been shown to block induced seizures in rats and mice. Supplemental betaine has also been shown to be effective in preventing various induced seizures in rats and in alleviating seizures in humans with homocystinuria. This is most evident in the transformation of homocysteine to methionine. ![]() Choline is converted to betaine when it acts as a methyl donor, whereas betaine is converted to DMG when it donates a methyl group. Gaetano Morello ND, in Textbook of Natural Medicine (Fifth Edition), 2020 Choline, Betaine, Dimethylglycine, and SarcosineĬholine, betaine (N,N,N,-trimethylglycine), dimethylglycine (DMG), and sarcosine have exhibited some anticonvulsant activity in human and animal studies. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
March 2023
Categories |